Aseptic filling - benchtop fillers

PF7+ peristaltic filling machine

Overview

PF7+ benchtop peristaltic filling machine

Developed for accurate and reliable filling of sensitive fluids in GMP production and cleanroom environments, the PF7 range of benchtop filling machines offer a reliable, flexible and scalable filling solution.

With only the inner bore of the single-use tubing coming into contact with the fluid, Flexicon benchtop filling machines remove the potential of cross contamination.

Flexion’s high-quality fillers are the perfect centrepiece for your final filling process. The PF7 range’s intelligent user interface, regulatory validation and simple operation combine to safeguard and drive efficiencies to your filling process. Developed through decades of engineering experiences, the PF7 benchtop filling machine range from Flexicon provides the perfect solution that can grow as you enhance, scale-up and look to introduce levels of automations your final fill/finish process. 

Paired with our Accusil tubing and asepticsu single-use assemblies, Flexicon benchtop filling machines provide an optimised filling performance while gently transferring product without affecting viability or quality.

 

Choosing the right product for your filling process

PF7+

PF7

Precision filling from micro-volumes

 ✔

Repeatable filling accuracies of better than ± 0.5% to prevent costly over filling 

No foaming, splashing or dripping between fills 

User-programmable ‘recipes’ where users can define filling recipe parameters

Connects to a range of balances and printers for error-free calibration and batch reporting to help compliance to GMP and regulatory demands 

Easy-to-clean surfaces with no entrapment areas, and an ergonomic design for operation on the bench or in isolators and LAF units

Clear and intuitive colour display with large keypad for easy use when gowned up in cleanroom environments

21 CFR part 11 compliance 

 

eBatch Reports via USB or EtherNet

 

USB keyboard

 

Zero waste start-up

 

100% in-process weigh checking

 

Dynamic recalibration

 

Colour fill tolerance indicators  

 

Features and benefits

  • Precision filling from micro-volumes
  • Repeatable filling accuracies of better than ± 0.5 % to prevent costly overfilling
  • No foaming, splashing or dripping
  • User-programmable ‘recipes’ where users can define filling recipe parameters
  • Easy-to-clean surfaces with no entrapment areas and an ergonomic design for operation on the bench or in isolators and LAF units
  • Clear and intuitive colour display with large keypad for easy use when gowned up in cleanroom environments
  • IQ/OQ documentation available
  • 5-year warranty

Technical summary

AccuracyBetter than ±0.5 %

Technical Summary table lists features available within the range. See ‘Technical specifications’ tab for model specific information.

Performance

Performance

Performance
Fill volume / ml Bore / mm (in) Typical fill time / s
0.2 0.5 (1/50) 0.75
1.0 0.8 (1/32) 1.10
1.4 1.2 (3/64) 0.75
1.8 1.6 (1/16) 0.60
8.0 3.2 (1/8) 0.70
15.0 4.8 (3/16) 0.80
24.0 6.0 (6/25) 0.80
50.0 8.0 (5/16) 0.80

Specifications

Technical specifications

PF7+PF7
Ingress ratingIP32, NEMA 2 IP32, NEMA 2 
Operating temperature range5 - 40 °C5 - 40 °C
Operating temperature range41 - 104 °F41 - 104 °F
Speed control ratio570:1 370:1 
Humidity(Non-condensing) 80% up to 31°C (88°F), decreasing linearly to 50% at 40C (104F) (Non-condensing) 80% up to 31°C (88°F), decreasing linearly to 50% at 40C (104F) 
StandardsCAN/CSA C22.2 No 61010-1, CE, cETLus, UL 61010-1 
Power supply50/60 Hz, Filtered 100-120 V/200-240 V, Single-phase 
Power consumption140 VA 140 VA 
Weight12.5 kg12.5 kg
Weight27.6 lbs27.6 lbs
Fuse rating2.5 amps2.5 amps
Compatible tubing size0.5-8.0 mm ID 0.5-8.0 mm ID 

Dimensions - PF7+

Rear panel
Feature Description
1 USB 2.0
2 M12 connectors
3 RJ45 10/100 Mbps(For export capability from pump only, not control use. Not designed for use with EtherNet/IP™. Not designed for use with PROFINET)
4 Voltage selector
5 Power switch
6 Power supply socket

Dimensions - PF7

Rear panel
Feature Description
1 USB 2.0
2 M12 connectors
3 Voltage selector
4 Power switch
5 Power supply socket

Materials of construction

CaseworkAnodized aluminum, Anodized aluminum EN AW-5754, Anodized aluminum EN AW-6060 T66
Keypad/HMIPolycarbonate, Polyester
Pumphead roller assemblyStainless steel AISI 304
Tube bridgeAnodized aluminum EN AW-5754

Literature

Brochures

  1. PF7+ brochure (US).pdf
    PDF - 405.7kb
  2. Flexicon overview (US).pdf
    PDF - 2.7mb

Datasheet

  1. PF7 datasheet.pdf
    PDF - 268.1kb
  2. PF7+ datasheet.pdf
    PDF - 273kb

Manuals

  1. Flexicon PF7 & PF7+ manual (EN).pdf
    PDF - 2.5mb

PF7+

PF7+

Advancements in bioprocessing through increasingly complex ATMPs and vaccines means that adopting smarter technologies into your final fill/finish process today is vital. With the increased complexity of cell line and gene therapies, Flexicon’s expertise in peristaltic filling ensures your high value product is protected from contamination and damage to viability.

Developed for critical aseptic final fill applications, PF7+ is an intuitive peristaltic filling pump. Our expert engineers have innovated to provide a no-waste solution, meaning more of your liquid can be used for viable product. Together with higher levels of product and production repeatability, PF7+ requires less operator interaction and simple set-up. When connected to the advanced filling kit  the PF7+ provides:

  • Zero waste start-up
  • 100% in-process weigh checking
  • Dynamic recalibration
  • Colour fill tolerance indicators

Enhancing the performance of your critical process

PF7+ is the ideal pump for every stage of your process development, from research and development, clinical trials and small batch production. With improved process traceability through electronic batch reporting and live audit trails via Ethernet, PF7+ removes the need to enter the cleanroom and provides access to a full audit trail with ease.

We have enhanced security through three user levels with unique permission, auto timeout locking and batch user password sign-off capabilities. 

  • 21 CFR part 11 compliance
  • eBatch Reports via EtherNet and removable USB
  • USB keyboard

Improved cleanability, ergonomics and safety with the QC14 pumphead

For ultimate cleanability, the QC14 pumphead (available on both PF7+ and PF7) features a hollow core and removable tray, allowing easy access for cleaning. The recessed locking leaver and secure tube bridge design affords users with single-handed tube loading operation while ensuring the tubing is loaded correctly.

  • Hollow core rotor design
  • Removable tray for easy cleaning
  • Autoclavable and gamma-irradiatable tube locks and tray
  • Additional safety sensors for removable parts
  • Ergonomic single lever design

For added safety the removable tray and tube bridge are fitted with safety switches that prevent operation of the pump unless both parts are securely in place. A redesigned tube bridge brings added drop protection for the critical track fingers. The pump has been factory calibrated and designed without the need for adjustment over the life of the pump.

PF7

PF7

PF7 is a flexible, reliable and versatile peristaltic filling machine. Developed to protect your valuable product in GMP production environments, PF7 provides a dependable, high-quality solution.

PF7 is the result of 30 years of industry-focused experience. PF7 is simple to operate, highly flexible whilst reducing the risk of errors and comes with Flexicon’s trademark precision. With an intuitive user interface, error-free calibration and batch reporting, PF7 helps to ensure GMP and regulatory compliance.

  • Precision filling from micro-volumes
  • Repeatable filling accuracies of better than ± 0.5% to prevent costly overfilling
  • No foaming, splashing or dripping between fills
  • Simple, powerful user interface
  • Designed for single-use fluid paths

Fast single-use fluid path changeover

Changing the fluid path can be achieved in less than a minute. The closed fluid path removes any risk of cross contamination, making the PF7 ideal for aseptic filling. Optimised for filling accuracy with Accusil tubing, the PF7 is designed to work with single-use fluid paths such as asepticsu.

Reliable and secure

The PF7 comes with a five year warranty. IQ/OQ documentation and execution available on request to assist with process validation.

Simple, powerful user interface

Large keys and a clear, colour display aids operation while working in gloves or behind glass within a RABS or LAF unit. The PF7 comes programmed with recommended filling parameters based on Flexicon’s 30-years of experience. Users can also set custom filling parameters of their own for optimum accuracy.

Integration into automated filling solutions

The PF7 will connect to a variety of bottle handling systems such as the FlexFeed 15, 20, and 30, or third-party systems. A range of accessories are available including footswitches for remote operation.

Improved cleanability, ergonomics and safety with the QC14 pumphead

For ultimate cleanability, the QC14 pumphead (available on both PF7+ and PF7) features a hollow core and removable tray, allowing easy access for cleaning. The recessed locking leaver and secure tube bridge design affords users with single-handed tube loading operation while ensuring the tubing is loaded correctly.

  • Hollow core rotor design
  • Removable tray for easy cleaning
  • Autoclavable and gamma-irradiatable tube locks and tray
  • Additional safety sensors for removable parts
  • Ergonomic single lever design

For added safety the removable tray and tube bridge are fitted with safety switches that prevent operation of the pump unless both parts are securely in place. A redesigned tube bridge brings added drop protection for the critical track fingers. The pump has been factory calibrated and designed without the need for adjustment over the life of the pump.

Advanced Filling Kit

Advanced Filling Kit

For a complete filling solution, Flexicon has worked with precision instrument specialists Mettler Toledo to develop a PF7+ advanced filling kit. Optimised and validated to eliminate compatibility risk, the advanced filling kit enables the PF7+ features of:

  • Zero waste start up
  • 100% in-process weight checking 
  • Dynamic recalibration 
  • Improved weighing accuracy 

To ensure filling repeatability, the PF7+ advanced filling kit includes a Mettler Toledo analytical balance with wind guarding and an integrated, adjustable nozzle holder. The kit also includes a set of custom weigh pans that allow for faster weight stabilisation in areas with laminar air flow and ensure proper repeatable positioning of the vial under the nozzle. The design gives extra protection to the weigh cell from accidental spillage.

The custom weigh pans accommodate a range of vial sizes including ISO standards up to 30R. 50R and 100R are additionally available.

Order Information

Product codes

Order information

Pump product codes
Description Partcode
PF7+ Peristaltic Filler 91-068-14X*
PF7+ Foot Pedal Switch 88-210-040
PF7+ Filling Stand 88-200-200
PF7+ IQOQ Protocol for 1 unit 74-156-440
PF7+ IQOQ Execution 74-156-431
PF7+ IQOQ Additional units 74-156-442
PF7/QC14 91-060-14X
PF7/QC12 91-060-00X
PF7 Foot Switch 88-010-040
PF7 Filling Stand 81-100-200
PF7 IQOQ Protocol 74-156-443
PF7 IQOQ Execution 74-156-444
FlexFeed 15 92-160-000
FlexFeed 20 92-170-000
FlexFeed 30 Contact local sales office
Advanced Filling Kit (up to 30R vials) 88-208-00X*
Advanced Filling Kit (50R-100R vials) 88-208-10X*
Wireless Cleanroom Keyboard 88-100-001
Field replaceable parts
QC14 pumphead for PF7+/PF7 87-068-000
QC14 tubebridge for PF7+/PF7 87-068-047
QC14 complete tubelock set 87-068-500
QC14 replacement access tray 87-068-055
Weigh pan set for Advanced Filling Kit 87-208-100
Plug options
U:UK mains plug
E:EU mains plug
A:American mains plug
K:Australia mains plug
R:Argentina mains plug
C:Swiss mains plug
D:India/South Africa mains plug
B:Brazilian mains plug
J:Israel mains plug
Accusil platinum-cured tube ordering codes
Bore / mm (in) Wall / mm (in) Length / m (ft) Part code
0.5 (1/50) 1.6 (1/16) 10 (32.8) 84-103-005
150 (492.1) 84-104-005
0.8 (1/32) 1.6 (1/16) 10 (32.8) 84-103-008
150 (492.1) 84-104-008
1.2 (3/64) 1.6 (1/16) 10 (32.8) 84-103-012
150 (492.1) 84-104-012
1.6 (1/16) 1.6 (1/16) 10 (32.8) 84-103-016
150 (492.1) 84-104-016
3.2 (1/8) 1.8 (1/14) 10 (32.8) 84-103-032
150 (492.1) 84-104-032
4.8 (3/16) 2.0 (10/127) 10 (32.8) 84-103-048
125 (410.1) 84-104-048
6.0 (6/25) 2.1 (10/127) 10 (32.8) 84-103-060
90 (290.3) 84-104-060
8.0 (5/16) 2.2 (2/23) 10 (32.8) 84-103-080
65 (213.2) 84-104-080

Recommended Products

  1. Accusil tubing

    Accusil tubing

    Tubing for accurate filling with excellent dispensing accuracy ± 0.5 %. Eight sizes available.

    Single-use assemblies

  2. FlexFeed 30

    FlexFeed 30

    Highly flexible solution for filling and capping of bottles. Handles screw, pipette or other caps with a special shape.

    Aseptic filling - semi-automatic handling

  3. FlexFeed 15/20

    FlexFeed 15/20

    Highly flexible solution for filling with no format parts for different vials/bottles up to 78 mm diameter.

    Aseptic filling - semi-automatic handling

  4. Fluid path accessories

    Fluid path accessories

    Filing and capping accessories including stands, weights, tube manifolds, Y-connectors and a range of filling nozzles.

    Fluid path - accessories

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